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Hi Stephanie I can't oblige with a specific example unfortunately, as the only recent example I have seen looks to be pretty decent quality (fortunately!) Question: In obese people (BMI ?30 kg/m2) with diabetes who inject insulin, are 5mm needles, as compared to 8mm, effective at maintaining glycaemic control and acceptable to patients? Original paper: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118929/ Blog post about it here: http://www.thediabeteself.net/uncategorized/5mm-needles-may-be-as-good-as-8mm-for-obese-patients-with-type-1-diabetes-or-type-2-on-insulin/ However, I was going to suggest that these sorts of examples are a great resource for all of us, so would you be willing to summarise and share your findings with the list? Also, and this may be of interest to the list in general, the CONSORT group are collating a Library of Examples (of good reporting practices) in RCTs. http://www.consort-statement.org/consort-library/ Conflict of interest: I host the above website, though I haven't been asked by anyone to post this message. cheers Douglas Stephanie Chan wrote: > Hello all, > > I'm preparing a lecture for my housestaff next week on how to read > noninferiority trials. I would love to hear any examples you may > recall of flawed noninferiority trials. Examples might include: > > -- A trial in which the experimental intervention was found to be > noninferior to the control, but the noninferiority margin was very wide. > > -- A trial in which the intervention was noninferior to the control, > but the control was little better than placebo. > > -- A trial in which noninferiority was found, but there were a large > number of drop-outs and cross-overs, minimizing any differences > between the groups. > > Thanks for your help and input! > > Stephanie > > > > -- > /Stephanie Chan, M.D./ > http://www.evidencebasedmommy.com/ > -- ------------------------- Mr Douglas Badenoch Director, Minervation Ltd ------------------------- 23 Bonaly Grove Edinburgh EH13 0QB ------------------------- Tel: +44 131 441 4699 Web: www.minervation.com ------------------------- Minervation is a limited company registered in England and Wales Registered number: 4135916 VAT number: 792674384 Registered Office: Salter's Boat Yard, Folly Bridge, Abingdon Road, Oxford, OX1 4LB, United Kingdom