Research positions are open to examine the molecular mechanisms underlying:
(1) Bacterial signalling mediated by the second messenger c-di-GMP
(2) AMP transfer onto target proteins mediated by Fic proteins
Background to the research project can be found in
Palanivelu, D. V., A. Goepfert, M. Meury, P. Guye, C. Dehio, and T. Schirmer. (2011). Fic domain catalyzed adenylylation: Insight provided by the structural analysis of the type IV secretion system effector BepA. Protein Sci. 20, 492.
Schirmer, T., and U. Jenal. (2009). Structural and mechanistic determinants of c-di-GMP signalling. Nat. Rev. Microbiol. 7, 724.
and on http://www.biozentrum.unibas.ch/open-positions
Tilman Schirmer
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