Hi,
At the Royal Liverpool Hospital, we have been working extensively with our LIMS supplier (iSoft iLab.TP, TelePath) to detect acute kidney injury (AKI) in
real-time. KDIGO guidelines recommend staging the condition according to changes in creatinine over 48 hours or a reference interval of 90 days (table below).
Stage
|
Serum creatinine (SCr) criteria
|
Urine output criteria
|
1
|
increase ¡Ã 26 ¥ìmol/L within 48hrs or
increase ¡Ã1.5 to 1.9 X reference SCr
|
<0.5 mL/kg/hr for > 6 consecutive hrs
|
2
|
increase ¡Ã 2 to 2.9 X reference SCr
|
<0.5 mL/kg/ hr for > 12 hrs
|
3
|
increase ¡Ã3 X reference SCr or
increase ¡Ã354 ¥ìmol/L or
commenced on renal replacement therapy (RRT) irrespective of stage
|
<0.3 mL/kg/ hr for > 24 hrs or anuria for 12 hrs
|
We are in the advanced stages of quality controlling this development and are seeking clarification on AKI Stage 3; do creatinine values have to attain a level of 354 umol/L or does the change from the reference creatinine within
the 90 day period need to be 354 umol/L? There are varying opinions about this.
There is also the issue of when a patient presents for the first time, when an AKI check cannot be performed and when there is a potential acute on chronic re-admission. We have some ideas on how this could be potentially detected,
but would welcome feedback from others.
Please respond directly and I will happily present a collated report to those interested.
Best wishes,
Adrian
___________________________________________
Dr Adrian G Miller BSc MSc PhD
Senior Clinical Biochemist
Department of Clinical Biochemistry & Metabolic Medicine
4th Floor, Duncan Building
Royal Liverpool and Broadgreen University NHS Trust
Daulby Road
Liverpool
L7 8XP
Tel. 0151 706 4163