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HI - it is correct that the "temporal" degrees of freedom is reduced by applying fsl_regfilt - however whether you need to correct for that later depends on what you are later doing. If you are running first-level FEAT then yes in theory you should correct, but if you are then going on to run higher-level FEAT it's not really necessary wrt the higher-level stats. Cheers. On 6 Oct 2011, at 18:40, Marina Shpaner wrote: > Dear experts, > > We are trying to figure out exactly how fsl_regfilt works. After we denoise the data with fsl_regfilt, do we need to adjust the degrees of freedom in the group analysis, and what's the proper way to do it? > > Your help is greatly appreciated! > -Marina > --------------------------------------------------------------------------- Stephen M. Smith, Professor of Biomedical Engineering Associate Director, Oxford University FMRIB Centre FMRIB, JR Hospital, Headington, Oxford OX3 9DU, UK +44 (0) 1865 222726 (fax 222717) [log in to unmask] http://www.fmrib.ox.ac.uk/~steve ---------------------------------------------------------------------------