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Thanks for the feedback. That makes sense - To clarify, if I were looking at the variance of the timecourse that is only related to my model, which 3D stats image(s) would I use to perform the calculation? Sean ________________________________ From: FSL - FMRIB's Software Library [[log in to unmask]] On Behalf Of Stephen Smith [[log in to unmask]] Sent: October 26, 2011 9:10 AM To: [log in to unmask] Subject: Re: [FSL] Model-related vs unrelated activity Hi - I'm not sure why you would want to form that as a 4D dataset, as it would be an outer product of a timecourse with a spatial map…..all the variance information you need can be summarised by the 3D stats images and the model timecourse. Cheers. On 25 Oct 2011, at 17:38, Sean McWhinney wrote: Hello FSL pros, I'm attempting to compare the variance of functional data that is a) related to and b) unrelated to, my model, within an ROI. For activity unrelated to my model, I've used res4d, which should suit this (but please correct me if I'm wrong). For activity related to the model, I'd intended to use cope1, but this is apparently only three dimensional, not four. Is there some way of looking at a participant's functional data that is only related to the model over time? Thanks in advance, Sean --------------------------------------------------------------------------- Stephen M. Smith, Professor of Biomedical Engineering Associate Director, Oxford University FMRIB Centre FMRIB, JR Hospital, Headington, Oxford OX3 9DU, UK +44 (0) 1865 222726 (fax 222717) [log in to unmask]<mailto:[log in to unmask]> http://www.fmrib.ox.ac.uk/~steve ---------------------------------------------------------------------------