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Hi, it has been suggested on the list to generate a set of RSNs from the "healthy" population and to run it against the "patient" group when large differences are expected. That's what I am trying to do because I have reason to assume so. I imagine this means running tcICA on both the control and the patient group separately and then (when calling the dual_regression script) using melodic_IC.nii.gz from the control.gica on the .filelist from the patient.gica - is that right? But how can I include possible additional/specific artefacts represented in the patient melodic_IC.nii.gz that might not necessarily be present or identical in the control group in the analysis? Fslmerge the ICAs of interest from the control melodic_IC into the patient melodic_IC and use that instead (and possibly throw out ICAs from the patient melodic_IC that look similar beforehand)? Did anyone do this succesfully and can advise? Thanks a lot, Cornelius -- Dr. med. Cornelius J. Werner Department of Neurology RWTH Aachen University Pauwelsstr. 30 52074 Aachen Germany