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Hi Carlos, Perhaps you could attach a snapshot of your design matrix and the contrasts that you are testing? cheers, -MH On Tue, 2011-09-06 at 23:48 +0100, Carlos Faraco wrote: > Dear FSL community, > > I asked a question related to this a few weeks ago, but now have a more basic question. > > I am looking at a FA and RD differences between a clinical group and controls. We have acquired various neurocognitive and neuropsychological measures on these groups. > > One set of scores that I am interested in are RBANS scores; a neurospsych test that includes various domains, e.g., immediate memory, delayed memory, visuospatial constructional skills, etc. > > Most of the scores show significant differences between the groups, except for visuospatial scores. In regards to FA and RD alone, I see no differences between the groups. > > My question is what does it mean to add these as EVs/confounds/whatever you want to call them in a randomise analysis? In other words, if I were to find some significant results indicating FA differences in regards to immediate memory, what additional information am I gathering from this that could be useful clinically? Similarly, what if I found significant results in regards to visuospatial scores, which didn't show any differences previously? > > I know that at a basic level the randomise results are indicating there is a difference in the slope of the scores. I just would like an explanation of the bigger picture. > > Many thanks, > > Carlos