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Hello May it is a know problem (or just for my installation ... ?) I have no problem with nifti files in INT16 but I notice a crash of fslview when I load nifti file with those datatype : data_type UINT16 data_type UINT32 Note that those 2 data type are correctly read with fslinfo (and it seems also to works with fslmerge) The nifti format datatype : #define DT_BINARY 1 // binary (1 bit/voxel) // is not supported at all. ... thanks Romain