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Avi uses spline interpolation for all his processing steps. FSL has an implementation of spline interpolation as well, but it is unlikely to be integrated into FEAT, which will use the default trilinear interpolation. I think changing to splines would be a worthwhile thing to do. :) Additionally, Avi's pipeline only resamples the images a single time, whereas FEAT likely resamples them multiple times. It is certainly possible to preprocess fMRI data using only FSL tools, but to use spline interpolation and a single resampling step; however, this requires custom scripts. Peace, Matt. -----Original Message----- From: FSL - FMRIB's Software Library [mailto:[log in to unmask]] On Behalf Of David Grayson Sent: Thursday, September 15, 2011 10:25 PM To: [log in to unmask] Subject: [FSL] fMRI data blurring Hi, I am am noticing that my fMRI data comes out somewhat blurred when I run through FSL's preprocessing stream (field-map unwarping, mcflirt, and slice timing correction) as compared to the 4dfp preprocessing stream (Avi Snyder's creation). Does anyone know why this might be? I have smoothing turned off, but is there some smoothing happening elsewhere I'm not taking into account? Thanks, David