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Dear all A postdoctoral position for a crystallographer/ enzymologist is available in the Division of Molecular Structure at the NIMR Medical Research Council National Institute for Medical Research Structure and mechanism of the retroviral restriction factor SAMHD1 Division of Molecular Structure A postdoctoral fellowship is available in the laboratory of Dr Ian Taylor to study the structre and mechanism of the recently described retroviral restriction factor, SAMHD1. The primary focus of the project will be to establish the relationship between the biochemical and enzymatic properties of SAMHD1 and the mechanism of virus restriction. The project will be carried out in close collaboration with the laboratory of Dr Jonathan Stoye. Candidates should have a thorough training in the practical aspects of structural and biochemical analysis of proteins as well as a good understanding of enzymolgy. Enthusiasm to advance the project as well as an understanding of retrovirology would be a significant advantage. The successful candidate will have a relevant PhD or be in the final stages of completing their PhD in biochemistry, biophysics or structural biology. Knowledge of basic molecular biology techniques and protein expression is essential. Previous experience in X-ray crystallography, enzyme kinetics and the use of biophysical techniques for the characterisation of protein complexes would be an advantage. Applicants should be able to learn quickly, have an interest in collaborative work, be able to communicate scientific ideas effectively and have a proven publication record. Contact Information: Informal inquires should be addressed to Dr. Ian Taylor via e-mail [log in to unmask] Situated in Mill Hill, North West London, the MRC National Institute for Medical Research is the largest MRC institute, supporting some 70 research groups and 500 bench scientists. The Institute provides excellent training for researchers in a multi-disciplinary environment and is equipped with state of the art facilities, including genetic modification of mice, imaging, histology, and high throughput sequencing. Salary range is from £27,513 per annum inclusive of London Allowance. MRC final salary Pension Scheme is available. Applications are handled by the RCUK Shared Services Centre; to apply please visit our job board at https://ext.ssc.rcuk.ac.uk and complete an online application form. Applicants who would like to receive this advert in an alternative format (e.g. large print, Braille, audio or hard copy), or who are unable to apply online should contact us by telephone on 01793 867003, Please quote reference number IRC26991. Closing date: 7 September 2011 Interview date: 20 – 22 September 2011 The MRC is an Equal Opportunities Employer Final appointments will be subject to a pre employment screening