Hi to all. I want to create and estimate an fMRI model in SPM8. I have whole BOLD/EPI images acquired on a 1.5T Sigma Scanner(General Electric). Each acquisition consists of 22 contiguos slices(3mmX3mmX3mm) with a TR of 3 sec. I have already made images pre-processing(realignment, normalization, smoothing,...). 441 acquisitions were made in blocks(on + off) of 21 scans, so I have 21 blocks of 21 scans. In each block(on + off) , I have 7 activation scans and 14 rest scans. I have three types of activations, presented in pseudo-random sequence, so I have 7 blocks for each condition I want test. The three conditions are electrical stimulations at different intensity. For example : off(14 scans) - condition1(7 scans) - off(14 scans) - condition3(7 scans) - off(14 scans) - condition1(7 scans) - off(14 scans) - condition2(7 scans) ..... and so on. I want to obtain activation map for each condition, so condition1 vs. rest, condition2 vs. rest, condition3 vs. rest. I have performed 1-st level analysis, but I haven't any activation for each condition. Belove, I desccribe parameters I have used for model specification : TIMING PARAMETERS : - Units for design : SCAN; - Interscan interval : 3 sec; - Microtime resolution : 16; - Microtime onset : 1; DATA & DESIGN : - Scans( all the 441 scans) ; - Onset( the scan at which the condition start) - Duration : 7; - High Pass Filter : 84 ; I have leaved all the other parameters set to default value. N.B. I have tried to consider only scans corresponding to the conditions I want to test(so 147 scans for each conditions), but I have obtained any result. Can anyone help me ? Thank you.