Hi Carsten, increase the bounding box at the 'write' section of your normalization parameters such that the entire volume of interest is included. Make sure the bounding box size is a multiple of your intended voxel size in each dimension. Good luck, Bas On 07/12/2011 05:58 PM, Carsten Finke wrote: > Hi Pablo, > many thanks for you answer! I have attached a screenshot - there you can see that (small) parts of the temporal lobe and the cerebellum are cut off. > And I actually chose the Segmentation and Normalization approach as a paper by Seghier et al. (2008) states that with this method additional lesion masking will bring no further benefit (hence, is not necessary)... The normalisation does indeed work great, just the little bit of the temporal lobe is missing... > > carsten -- -------------------------------------------------- Dr. S.F.W. Neggers Division of Brain Research Rudolf Magnus Institute for Neuroscience Utrecht University Medical Center Visiting: Heidelberglaan 100, 3584 CX Utrecht Room B.01.1.03 Mail : Huispost B.01.206, P.O. Box 85500 3508 GA Utrecht, the Netherlands Tel : +31 (0)88 7559609 Fax : +31 (0)88 7555443 E-mail : [log in to unmask] Web : http://www.neuromri.nl/people/bas-neggers http://www.neuralnavigator.com --------------------------------------------------