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True that CA 125 is NOT diagnostic of ovarian cancer. However, ... Is ascites in the case malignancy-related ? Any other etiology ? CA 125 1500 kU/L is not necessarily the range one would expect in benign conditions. You may add HE 4 and calculate ROMA. Best regards, Mike Priv.-Doz. Dr. med. Michael Steiner Medizinisches Labor Rostock Suedring 81 D-18059 Rostock [log in to unmask] -----Ursprüngliche Nachricht----- Von: Clinical biochemistry discussion list [mailto:[log in to unmask]] Im Auftrag von Colley, Michael Gesendet: Montag, 18. Juli 2011 16:29 An: [log in to unmask] Betreff: Re: CA125 Should be accompanied by a note saying something like "CA125 is increased in all cases of ascites. Level tends to be related to the degree of ascites. NOT diagnostic of Ovarian cancer" I don't do it on patents with ascites 'cos it's meaningless (except as a measure of whether their ascites is getting better or worse). Michael -----Original Message----- From: Clinical biochemistry discussion list [mailto:[log in to unmask]] On Behalf Of David Burgess Sent: 18 July 2011 15:27 To: [log in to unmask] Subject: CA125 May I ask your opinion. A 50 y.o. woman, an inpatient on the gynae ward, bleeding p.v. and with ascites and hydronephrosis has a CA125 1500 kU/L (N<35). There are no previous measurements. Should her results be accompanied by a cautionary note e.g. " may be raised in a number of benign conditions including endometriosis, inflammatory pelvic disease and acites"? Also should her results be phoned to the ward? Regards, David ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk Green Laboratories Work http://www.laboratorymedicine.nhs.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/