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Dear Haoran, There are two answers to that. The first answer is that whether there is any signal in the MEG from amygdala or hippocampus is subject to debate and there is some evidence in favor of that but it's not conclusive. The second answer is that you can include sources in your DCM model even if there is no signal in the MEG/EEG from these sources and learn something about those 'hidden' source from their interactions with sources that are observed. As an example you can look at http://www.ncbi.nlm.nih.gov/pubmed/21325540 . You can either just place sources e.g. in the hippocampus the usual way or (in an up-to-date SPM) if you specify the position further that 200mm from the origin (like [300 300 300]) the lead field of the source will be set to zero and then it will be truly hidden source. You can compare the two ways with model comparison to see if there is really any evidence for the source being at particular location or not. Best, Vladimir 2011/6/9 飞鸟 <[log in to unmask]>: > Dear spm's users, > Thanks for your concern! As DCM for EEG/MEG is based on nerual mass model, > I wonder that can I apply DCM for EEG/MEG to cerebral limbic system( such as > cingulate, hippocampus and amygdala etc). In other words, is it valid to > specify my model not only include cortex regions(e.g. frontal lobe, temporal > lobe etc.), but also include cingulate or other limbic system's regions? > Any help will be appreciated! > > -- > Haoran LI (MS) > Brain Imaging Lab, > Research Center for Learning Science, > Southeast University > 2 Si Pai Lou , Nanjing, 210096, P.R.China > >