Hi thanks for the reply. To be a little more specific with my question in regards to conditon A (post-pre) vs condition B (post-pre). If I follow the standard paired t-test design, it would look like this for condition A's post-pre setup, but how do I compare, for example condition A (post-pre) - condition B (post-pre)?: EV1 EV2 - EV7 (one EV for each subject) Input 1 (subject 1, condition A, pre) 1 Input 2 (subject 2, condition A, pre) 1 Input 3 (subject 3, condition A, pre) 1 Input 4 (subject 4, condition A, pre) 1 Input 5 (subject 5, condition A, pre) 1 Input 6 (subject 6, condition A, pre) 1 Input 7 (subject 1, condition A, post) -1 Input 8 (subject 2, condition A, post) -1 Input 9 (subject 3, condition A, post) -1 Input 10 (subject 4, condition A, post) -1 Input 11 (subject 5, condition A, post) -1 Input 12 (subject 6, condition A, post) -1 I hope this makes sense... Thanks On Wed, Jun 1, 2011 at 1:14 AM, Stephen Smith <[log in to unmask]> wrote: > Hi - see the FEAT and randomise manuals - this is a standard paired t-test > design that you can setup with the Glm GUI and then use that saved design > when running randomise. > Steve. > > > On 31 May 2011, at 21:48, Amy wrote: > > Hi all, > > I have 6 subjects scanned twice under 2 different conditions. Within each > condition (each scan), subjects underwent a pre-intervention and a > post-intervention resting state fmri. I want to run dual regression > comparing the 2 different conditions to see if there are any significant > differences. However, I am not sure how to set up the design in the glm. If > I want to compare Condition A's post-pre to Condition B's post-pre, how > would I set that up? Using the FEAT, I can run multiple higher level > analyses using the COPE images, but with the model-free resting state > analysis, I'm not sure I can find an option like that. I'd greatly > appreciate it if anyone has any ideas on how I can do this. Thanks! > > > > --------------------------------------------------------------------------- > Stephen M. Smith, Professor of Biomedical Engineering > Associate Director, Oxford University FMRIB Centre > > FMRIB, JR Hospital, Headington, Oxford OX3 9DU, UK > +44 (0) 1865 222726 (fax 222717) > [log in to unmask] http://www.fmrib.ox.ac.uk/~steve > --------------------------------------------------------------------------- > > > >