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Hi Ewan,
 
Is he heterozygous FH?
 
You have no other choice left, Questran or surgery (partial ileal bypass).
 
Regards
 
 
Mohammad
 
Dr. M A Al-Jubouri, MB ChB, MSc, FRCP Edin, FRCPath
Consultant Chemical Pathologist


From: Clinical biochemistry discussion list [mailto:[log in to unmask]] On Behalf Of Bell Ewan (NHS DUMFRIES & GALLOWAY)
Sent: 13 June 2011 15:50
To: [log in to unmask]
Subject: To Lipidologists

 

Hi

 

I have a 53 year old male with a cholesterol of 10, normal trigs and HDL. He has hypertension but no vascular history. He has no family history. LFTs, UEs, TFTs all normal with negative ACR.

 

He has been on lowest dose simvastatin, pravastatin, atorvastatin, rosuvastatin, which he can't tolerate due to myositis (indeed on rosuvastatin his CK went up to 1,500). Fibrates and ezetimibe weren't tolerated. Tredaptive was tolerated but didn't work (cholesterol still 10).

 

What do I do next?

 

Thanks for your help,

 

Ewan

 

Dr Ewan Bell

Clinical Director - Diagnostics

NHS Dumfries and Galloway

UK


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