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Hi Helmut, > is there any strong opinion or even objective evidence [literature] > for/against using SVD (vs. the mean) when working with data extracted > from a VOI? I searched the literature for this a while ago and found that two good references were Saxe et al., NI 2006, arguing for the mean, vs. Friston et al., NI 2006 (same issue, I think), arguing for the first eigenvariate, so there seems to be a certain degree of uncertainty :) I have not seen an exhaustive simulation definitely favoring the one over the other. Cheers, Marko Saxe R, Brett M, Kanwisher N, 2006. Divide and conquer: a defense of functional localizers. NeuroImage 30: 1088-1096 Friston KJ, Rotshtein P, Geng JJ, Sterzer P, Henson RN, 2006. A critique of functional localisers. NeuroImage 30: 1077-1087 -- ____________________________________________________ PD Dr. med. Marko Wilke Facharzt für Kinder- und Jugendmedizin Leiter, Experimentelle Pädiatrische Neurobildgebung Universitäts-Kinderklinik Abt. III (Neuropädiatrie) Marko Wilke, MD, PhD Pediatrician Head, Experimental Pediatric Neuroimaging University Children's Hospital Dept. III (Pediatric Neurology) Hoppe-Seyler-Str. 1 D - 72076 Tübingen, Germany Tel. +49 7071 29-83416 Fax +49 7071 29-5473 [log in to unmask] http://www.medizin.uni-tuebingen.de/kinder/epn ____________________________________________________