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Hi Spmrs, I'm working FMRI files and then the preprocessing (realignment, time slicing, etc.), I would like to extract time series (temporal behaviour of the signals from cerebellum). I have obtained the design matrix through the First model Specification in SPm. From manual, I saw that I should define the T and F contrasts . Is it correct? How do I define these contrasts? Thanks for your answers. G.S.