Dear Nij,

It would be interesting for this list to see what you manage to compile. I, in particular, would be interested to see the results of the trials expressed in relative risk reductions (RRR) and absolute risk reduction (ARR).

Best wishes,

Jeremy

From: Neeraj Bhala <[log in to unmask]>

Reply-To: Neeraj Bhala <[log in to unmask]>
Date: Wed, 11 May 2011 16:03:21 +0100
To: "[log in to unmask]" <[log in to unmask]>

Subject: Large-scale randomised trials?

Dear colleagues,

 

My name is Neeraj (‘Nij’) Bhala and I am an epidemiologist in Oxford.  Mike Clarke (previously of the UK Cochrane Centre and now Director of the All-Ireland Hub for Trials Methodology Research) and  I are putting together a list of the large simple randomised trials of healthcare interventions therapies (excluding vaccines and screening) with more than 10,000 participants.

 

Do any of you have any suggestions for other large randomised trials we might have missed (including their size), people to ask or places to look?

 

Trials greater than 20,000
Women's Health Initiative
Physicians' Health Study
Women's Health Study
ISIS-3
ISIS-4
GUSTO-1
Chinese Acute Stroke Trial (CAST)
ALLHAT
Heart Protection Study
COMMIT-CCS2
OASIS-5 (MICHELANGELO)

 CRASH-2

 

We look forward to hearing from you.

 

Kind regards,

 

Neeraj and Mike