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If you're interested in nutrition, our Cochrane review of vitamin A includes 9 trials with more than 10k. We're working on a similar project about zinc now. http://www2.cochrane.org/reviews/en/ab008524.html Best wishes, Evan Evan Mayo-Wilson Departmental Lecturer University of Oxford Centre for Evidence-Based Intervention Barnett House 32 Wellington Square Oxford OX1 2ER, UK mobile: +44 (0) 7932 116535 [log in to unmask] On 11 May 2011 18:04, Jeremy Howick <[log in to unmask]> wrote: > Dear Nij, > > It would be interesting for this list to see what you manage to compile. I, > in particular, would be interested to see the results of the trials > expressed in relative risk reductions (RRR) and absolute risk reduction > (ARR). > > Best wishes, > > Jeremy > > From: Neeraj Bhala <[log in to unmask]> > Reply-To: Neeraj Bhala <[log in to unmask]> > Date: Wed, 11 May 2011 16:03:21 +0100 > To: "[log in to unmask]" < > [log in to unmask]> > > Subject: Large-scale randomised trials? > > Dear colleagues, > > > > My name is Neeraj (‘Nij’) Bhala and I am an epidemiologist in Oxford. Mike > Clarke (previously of the UK Cochrane Centre and now Director of the > All-Ireland Hub for Trials Methodology Research) and I are putting together > a list of the large simple randomised trials of healthcare interventions > therapies (excluding vaccines and screening) with *more than 10,000*participants. > > > > Do any of you have any suggestions for other large randomised trials we > might have missed (including their size), people to ask or places to look? > > > > *Trials greater than 20,000* > > Women's Health Initiative > > Physicians' Health Study > > > > Women's Health Study > > > > ISIS-3 > > > > ISIS-4 > > > > GUSTO-1 > > > > Chinese Acute Stroke Trial (CAST) > > > > ALLHAT > > > > Heart Protection Study > > > > COMMIT-CCS2 > > > > OASIS-5 (MICHELANGELO) > > > > CRASH-2 > > > > We look forward to hearing from you. > > > > Kind regards, > > > > Neeraj and Mike >