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This is not my experience. Provided the solvent is featureless, I find that a high solvent contents leads to a lower Rfree due to a kind of solvent flattening effect. Of course, if a significant part of the molecule(s) is/are disordered, this will lead to a degradation of the Rfree. My 2 cents, Herman -----Original Message----- From: CCP4 bulletin board [mailto:[log in to unmask]] On Behalf Of Clement Angkawidjaja Sent: Tuesday, May 24, 2011 10:47 AM To: [log in to unmask] Subject: Re: [ccp4bb] how to remove part of data with bad signal to noise ratio Hi Seema, Small addition to the already abundant suggestions, if you have high solvent content or significant portion of non-observable density, you normally get higher R-free. Clement #################################################### Clement Angkawidjaja, PhD. G30 Assistant Professor ------------------------------------------------------------------------ ------------------- Chemistry-Biology Combined Major Program International College, Osaka University 1-30 Machikaneyama-cho Toyonaka, Osaka 560-0043, Japan http://cmp.sci.osaka-u.ac.jp/CMP/ Tel. +81-6-6850-5952 Fax +81-6-6850-5961 ------------------------------------------------------------------------ ------------------- Laboratory of Molecular Biotechnology Graduate School of Engineering Osaka University 2-1 Yamadaoka U1E-804 Suita, Osaka 565-0871, japan http://www.mls.eng.osaka-u.ac.jp/~bio_ext/mlsbe123/clement.html Tel/Fax +81-6-6879-4157 ####################################################