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Hello, I agree with Michael Collins! There is little point in measuring iron (poisoning excluded and there is no need to measure TIBC in a case of poisoning), transferrin is an acute phase reactant which complicates the situation, then to make matters worse there is anaemia of chronic disorder. If it's necessary to assess an individual's iron status then we should measure' hepcidin'; those of us old enough will remember reading the elctrolyte section in books referring to the 'third factor' before natriuretic hormones were discovered. John Martin ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk Green Laboratories Work http://www.laboratorymedicine.nhs.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/