Hi

It is true that traceability requires good analytical specificity, and changing the basis of standardisation will not affect this.  However, placing standardisation on a firm scientific foundation enables the diagnostic industry to improve the specificity of its methods over time, and from this effort new information may arise.

We know that whereas the measurand is the same (concentration of HbA1c in whole blood), the entity(ies) that give(s) the signal in the assay system will depend on the technology used (ion exchange, affinity chromatography, immunoassay). However, because we now have a defined primary standard and a proper reference method calibrated by that standard, we know how to measure the concentration of HbA1c in a matrix using a fundamentally more accurate technology.  Field methods may take a little while to catch up, but at least now we have a basis for assessing their closeness of agreement with as near to the 'truth' as we can get.

I think your statement about the arbitrariness of the units and the quotes around the word 'scientific' are incorrect.  This has been a scientific process and the new units have a strong rational basis.

Cheers

Jonathan Middle


     

On Mon, May 9, 2011 at 2:32 PM, Reynolds Tim <[log in to unmask]> wrote:
But we are still measuring a mixture by the same old method, so any result expressed inthe new IFCC units is just as much a fudge as it was in the old units. So, the likelihood of new knowledge coming out of the new units is quite slim.
 
And mst of the GPs I have spoken to also believe we should ignore National guidance because they can see no reason to change from one arbitrary ratio, to another arbitrary 'scientific' ratio.
 
TIM



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-----Original Message-----
From: Clinical biochemistry discussion list [mailto:[log in to unmask]] On Behalf Of Jonathan Middle
Sent: 09 May 2011 14:23
To: [log in to unmask]
Subject: Re: End of dual reporting of HbA1c

Hi again

At that time we were just changing the concentration units.

The situation with HbA1c is different - we are changing the whole basis of standardisation from calibration by correlation with a non-specific 'designated comparison method', to calibration using a highly specific reference measurement system with a full traceability chain. 

I believe that the importance of this and the potential for generating new knowledge that it generates has not been properly communicated to users

Regards

Jonathan Middle.

 

On Mon, May 9, 2011 at 2:11 PM, Mike Howell <[log in to unmask]> wrote:
Hi

Back in the early 1970s we changed virtually all our reference ranges from imperial to SI units practically overnight.

I don't remember dual reporting then.

Mike


Mike Howell
Clinical Biochemistry
The Hillingdon Hospital
Pield Heath Road
Uxbridge
Middx
UB8 3NN
Tel 01895 279225


>>> Jonathan Kay <[log in to unmask]> 09/05/2011 13:21 >>>
Spot the quote:

"Never give in--never, never, never, never, in nothing great or small, large or petty, never give in except to convictions of honour and good sense. Never yield to force; never yield to the apparently overwhelming might of the enemy."

Jonathan


On 9 May 2011, at 13:17, John Francis Doran (ABM ULHB - Biochemistry) wrote:

> Many of us have agreed to 1st June. The problem is that users are still in denial and will be until we switch. Do it now and show backbone!
> As far as the user leaflets are concerned, how did we get a reference to "glycosylated haemoglobin" in the patient's leaflet only?
> John
>
> From: Clinical biochemistry discussion list [mailto:[log in to unmask]] On Behalf Of Julian Barth
> Sent: 09 May 2011 10:24
> To: [log in to unmask]
> Subject: Fwd: End of dual reporting of HbA1c
>
> Dear Colleague
>
> Two years ago we agreed at a multi-agency consensus meeting to report HbA1c in both DCCT and IFCC units for a two year period in order to give clinicians and patients time to learn the new units. This change to IFCC units was necessary as there was no solid international standard for DCCT units. At that time we (ACB and Diabetes UK) produced information leaflets for the education of all people involved in diabetes care. However, despite the looming date of 1st June, it is apparent that not everyone is ready for DCCT to be switched off. It has therefore been agreed that there should be a one-off delay to the switch off of DCCT units until 1st October.
>
> I am attaching a set of the educational leaflets and would be grateful if you would distribute them again to all your users with notification that DCCT will not be reported after 30th September.
>
> Best wishes
> Julian Barth
>
> President
> Association for Clinical Biochemistry


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