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I made the following notes a few years ago in our reference range, system based on the following reference: Bansal et al, Nordestgaard et al and McBride (editorial) JAMA. 2007; 298: 299-308, 309-316, 336-338. "Although national guidelines recommend that blood for lipid profiles be taken after an 8 to 12 hour fast, studies published in 2007 suggest that triglyceride levels measured 2 to 4 hours post-prandially have a stronger association with cardiovascular events than fasting levels. It is suggested that high levels of non-fasting triglycerides levels could reflect either a higher peak level or a delay in the clearance of triglyceride-rich particles and that elevated non-fasting triglyceride levels indicate the presence of remnant lipoproteins, which may promote atherosclerosis. Triglyceride levels measured within 2 hours of a meal showed no association with cardiovascular events." Hope that adds something to the discussion. Best wishes, Elliott ________________________________________ From: Clinical biochemistry discussion list [[log in to unmask]] On Behalf Of John Francis Doran (ABM ULHB - Biochemistry) [[log in to unmask]] Sent: 03 May 2011 13:27 To: [log in to unmask] Subject: Re: two fasting lipid questions - a) paediatric, b) water Why do you want fasting lipids, and especially for DM, I assume type 1? Does it really make any difference? John -----Original Message----- From: Clinical biochemistry discussion list [mailto:[log in to unmask]] On Behalf Of Peadar McGing Sent: 03 May 2011 12:02 To: [log in to unmask] Subject: two fasting lipid questions - a) paediatric, b) water Dear colleagues, Two queries to which somebody may have answers readily available. Question 1 is what length of time should a child fast for fasting lipids? This is a query passed to me by a colleague in a paediatric lab. They are reviewing their protocols which currently state 12 hours fast except for babies where they specify take bloods before the next feed. Also should the time change (reduce) for diabetics. I have some published protocols for when fasting or non-fasting lipids should be measured but not what duration of fast. Question 2 relates to drinking water as part of a fast pre fasting lipids or glucose. We recommend drinking normal amounts of water during their fast but I would like to get a reference to quote in support of this. Does anyone have a reference to a journal paper or review supporting (or not) consumption of water during a pre-blood test fast? Any help would be appreciated. best wishes. Peadar Dr Peadar McGing, FRCPath EurClinChem, Principal Biochemist, Biochemistry Dept., Mater Misericordiae University Hospital, Eccles Street, Dublin 7, Ireland. 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