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A couple of comments: (1) VBM will determine differences in volume and/or tissue probability. If you want to know about thickness, then you should use Freesurfer. (2) You need a set of normal control subjects scanned with the same protocol to make group comparisons. A template image will only provide a space to which images can be normalized. You won't be able to use the template to find out if your group is different from healthy control subjects. (3) You need to more specific about what you want to do with your ROIs and what type of ROIs you are wanting to create. Best Regards, Donald McLaren ================= D.G. McLaren, Ph.D. Postdoctoral Research Fellow, GRECC, Bedford VA Research Fellow, Department of Neurology, Massachusetts General Hospital and Harvard Medical School Office: (773) 406-2464 ===================== This e-mail contains CONFIDENTIAL INFORMATION which may contain PROTECTED HEALTHCARE INFORMATION and may also be LEGALLY PRIVILEGED and which is intended only for the use of the individual or entity named above. If the reader of the e-mail is not the intended recipient or the employee or agent responsible for delivering it to the intended recipient, you are hereby notified that you are in possession of confidential and privileged information. Any unauthorized use, disclosure, copying or the taking of any action in reliance on the contents of this information is strictly prohibited and may be unlawful. If you have received this e-mail unintentionally, please immediately notify the sender via telephone at (773) 406-2464 or email. On Sat, Apr 16, 2011 at 1:36 AM, M.G. Ramesh Babu [MU-KMCIC] < [log in to unmask]> wrote: > Dear SPMers, > I am planning to do a voxel based morphometric study on the MRI scan of > headache patients. I need your suggestion regarding the use of template > image. We have 30 MRI data of the migraine patients. All are reported as > normal. I want to find out changes (increase or decrease thickness) in > certain brain region, for eg. hypothalamus by VBM procedure. To say increase > or decrease in the thickness i have to compare the images with normal > anatomical image (template). right? But I don't have normal subjects data. > In such case what procedure should I follow to find out the structural > changes in the brain? This is my first MRI study. So need your help. > > And I need tutorial for ROI. If any one have this tutorial or any web link > please send it to me. > > Waiting for your reply > > With thanks > Ramesh > Manipal University > India. >