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Thanks for your reply. It is accordant with what I just mentioned in my email. My main question was: Do you know of any comprehensive study that provides proof on it? Have the results of tensorial ICA applied on resting-state fmri been compared to the results of the time concatenated ones in any journal paper? Best, Mona ________________________________ From: FSL - FMRIB's Software Library [[log in to unmask]] on behalf of Eugene Duff [[log in to unmask]] Sent: Wednesday, April 27, 2011 1:30 PM To: [log in to unmask] Subject: Re: [FSL] tensorial ICA applied on resting-state fMRI Hi Mona - Tensorial ICA looks for components showing a consistent time course across sessions/subjects. As there is no task in resting state that will drive a temporal sequence of neural activity that is consistent across sessions/subjects, Tensorial ICA is inappropriate. I hope that helps - Eugene -- Eugene Duff, Phd Analysis Group, Centre for Functional MRI of the Brain (FMRIB) Nuffield Department of Clinical Neurosciences John Radcliffe Hospital University of Oxford, OX3 9DU Ph: +44 (0) 1865 222 523 -- On 27 April 2011 18:14, Mona Maneshi <[log in to unmask]<mailto:[log in to unmask]>> wrote: Dear FSL experts, Hi, I am using MELODIC both for its implemented temporal concatenation approach and the tensorial ICA. Through the FSL website one can infer that the tensorial ICA is not recommended for resting-state study since it assumes the same temporal response across runs/sessions/subjects. Where it says: "It is recommended to use this approach for data where the stimulus paradigm is consistent between session/subjects. Tensor-ICA assumes that the temporal response pattern is the same across the population and provides a single decomposition for all original data sets. MELODIC will attempt to find components which are highly non-Gaussian relative to the full mixed-effects variance of the residuals." Do you know of any comprehensive study that provides proof on it? Have the results of tensorial ICA applied on resting-state fmri been compared to the results of the time concatenated ones in any journal paper? I would appreciate your care in advance, Best, Mona