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Hello, we would like to run only the post-stats part of a melodic analysis, using a set of already obtained ICs. Is it possible to run mixture modelling on this maps indicating a Subjects design and Subjects contrast matrices? We have tried already this option and it seems that melodic is concatenating timeseries of all the subjects, we used this command: melodic -i .filelist - -ICs=groupmelodic.ica/melodic_IC.nii.gz - -mix=groupmelodic.ica/melodic_mix --Sdes=../design.mat --Scon=../design.con --report -o outdir -a tica -v When doing the standard procedure (putting Sdes inside Melodic GUI) we realized that spatial maps of the components are slightly different between analyses. thank you Eva