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Could see a big rise in requests because of this. (good job it costs less than our tariff price I love PBR) To the best of my knowledge the RCOG guideline 34 (2003) is still very useful advice on this: "Serum CA125 is well established being raised in over 80% of ovarian cancer cases, if a cut-off of 30 u/ml is used, the test has a sensitivity of 81% and specificity 75%. Ultrasound is also well established, achieving a sensitivity of 89% and specificity of 73% when using a morphology index" They go on to recommend the calculation of a risk of malignancy index Table 1. Calculating the risk of malignancy index (RMI); these are modifications of the original RMI using modified scores RMI = U x M x CA125 U = 0 (for ultrasound score of 0); U = 1 (for ultrasound score of 1); U = 3 (for ultrasound score of 2-5) Ultrasound scans are scored one point for each of the following characteristics: multilocular cyst; evidence of solid areas; evidence of metastases; presence of ascites; bilateral lesions. M = 3 for all postmenopausal women dealt with by this guideline CA125 is serum CA125 measurement in u/ml Table 2. An example of a protocol for triaging women using the risk of malignancy index (RMI); data from validation of RMI by Prys Davies et al.16 Risk RMI Women (%) Risk of cancer (%) Low < 25 40 < 3 Moderate 25-250 30 20 High > 250 30 75 Link http://www.rcog.org.uk/files/rcog-corp/GTG3411022011.pdf Cheers John ________________________________ From: Clinical biochemistry discussion list [mailto:[log in to unmask]] On Behalf Of Jonathan Kay Sent: 27 April 2011 00:39 To: [log in to unmask] Subject: Simple blood test could save hundreds from ovarian cancer - Health News, Health http://www.independent.co.uk/life-style/health-and-families/health-news/ simple-blood-test-could-save-hundreds-from-ovarian-cancer-2275152.html Jonathan ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk Green Laboratories Work http://www.laboratorymedicine.nhs.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/ ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk Green Laboratories Work http://www.laboratorymedicine.nhs.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/