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Hi Natalie, > My question concerns the effect that the glasbrain is just poorly > filled. It seems like there are strong extinctions in frontal, > frontoparietal and temporal brain regions. Do you know why this happens? Since you are using DARTEL, it is not unusual for your brains not to exactly match the glass brain (which is only an idealized brain anyway). More important is the question of whether the functionals match the anatomicals correctly (which you can see by overlaying your result on the final iteration DARTEL template), whether normalization worked for all subjects (which you can see using check_reg) and whether data from all subjects was available for all parts of the brain (which you can see when you look at the mask.img in your analysis directory). If all of this looks good, then I would overlay the results on the template used for spatial normalization and not worry about it anymore :) Hope this helps, Marko -- ____________________________________________________ PD Dr. med. Marko Wilke Facharzt für Kinder- und Jugendmedizin Leiter, Experimentelle Pädiatrische Neurobildgebung Universitäts-Kinderklinik Abt. III (Neuropädiatrie) Marko Wilke, MD, PhD Pediatrician Head, Experimental Pediatric Neuroimaging University Children's Hospital Dept. III (Pediatric Neurology) Hoppe-Seyler-Str. 1 D - 72076 Tübingen, Germany Tel. +49 7071 29-83416 Fax +49 7071 29-5473 [log in to unmask] http://www.medizin.uni-tuebingen.de/kinder/epn ____________________________________________________