Hi Linling It might be that MRicro is showing you the coordinates in Talairach space and SPM in MNI space. I noticed in your attached MRIcro jpg image that there is a little checkbox to the left of the coordinates which says “tal2mni”. Try checking this and see if they correspond better. Cheers -Bill From: SPM (Statistical Parametric Mapping) [mailto:[log in to unmask]] On Behalf Of Linling Li Sent: Wednesday, 23 March 2011 5:20 PM To: [log in to unmask] Subject: [SPM] Problem with MRIcro Dear all, When I was using MRIcro to show the activation of a T-contrast image, I found the activation pattern was slightly different from the activation showed by SPM. I would explain this through two pictures I attached with this email. As we could see from the whole brain statistics picture, voxel which coordinate was (9, -34, -20) (red one) had a T value of 2.16. However, when I select this voxel via MNI coordinate in MRIcro, it showed there was no activation (the T value was below the threshold, there was no T value showed following its coordinate in the lower left quarter). Had MRIcro done someting to the T-contrast functional image? Hope someone could help me with this. Thank you all in advance! Best wishes! 2011-03-23 _____ 李琳玲 Linling Li Research Centre for Neural Engineering -------------------------------------- Phone: +86-755-86392232 Email: [log in to unmask] Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences.