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Marisa, Are you using the con* images for each subject (so 26 files) OR are you using the con* images form the one-sample t-test (so 2 files)? If your using the later, its not surprising it fails as the residuals are 0. If you are using the former, make sure all the con* files have data that overlap. Best Regards, Donald McLaren ================= D.G. McLaren, Ph.D. Postdoctoral Research Fellow, GRECC, Bedford VA Research Fellow, Department of Neurology, Massachusetts General Hospital and Harvard Medical School Office: (773) 406-2464 ===================== This e-mail contains CONFIDENTIAL INFORMATION which may contain PROTECTED HEALTHCARE INFORMATION and may also be LEGALLY PRIVILEGED and which is intended only for the use of the individual or entity named above. If the reader of the e-mail is not the intended recipient or the employee or agent responsible for delivering it to the intended recipient, you are hereby notified that you are in possession of confidential and privileged information. Any unauthorized use, disclosure, copying or the taking of any action in reliance on the contents of this information is strictly prohibited and may be unlawful. If you have received this e-mail unintentionally, please immediately notify the sender via telephone at (773) 406-2464 or email. On Wed, Mar 2, 2011 at 2:43 AM, Marisa Loitfelder < [log in to unmask]> wrote: > Hi, > > I want to do a paired t-test with 13 subjects' pre/post scans. By loading > in the con*-files of one sample t-test of each point in time I always get > the error: "please check your data. there are no significant voxels." > What can I do against this? > > Thanks, > Marisa >