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Dear FSL users, I want to compare three groups which corresponds to 3 stages of a disease. I don't really understand how can I do: 1) Is it better to do a t-test or an ANOVA? 2) I don't really understand how to build the design. I would like to do this: EV1 (stage A) EV2 (stage B) EV3 (stage C) 1 0 0 1 0 0 1 0 0 0 1 0 0 1 0 0 1 0 0 0 1 0 0 1 0 0 1 and I would like to contrast each group with the others: A vs B -1 1 0 A vs B 1 -1 0 B vs C 0 1 -1 B vs C 0 -1 1 A vs C 1 0 -1 A vs C -1 0 1 3) I have another problem: I have a lot of covariables: age, sexe (binary value), alcohol addiction (binary value), drug addiction (binary value) and presence of treatment (binary value). I demean age for each group or for the entire sample? 4) Have I to change the column "group" given by defaukt by the GLM GUI? Thanks for all, C.