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Hi Gwenaëlle, Concerning your recent paper "DTI measures in crossing-fibre areas: Increased diffusion anisotropy reveals early white matter alteration in MCI and mild Alzheimer's disease": 1. what is the average number of particles that you analyzed? "we counted for each subject the average number of particles within the crossing fiblre ROI which "belonged" to ..." is it the product of: fslstats -M * fslstats -V or maybe the waytotal? 2. did you threshold each subjects tractography (if so what was the threshold that you used)? Thanks and all the best, Kasia