Hi Aditya, > I have run the FSL VBM to look for differences across two > groups patients & controls. Is there a way to quantify > the differences that are obtained? I am not sure I understand your question... But if you are looking at the significance of the GM differences between your two groups, then you simply need to use randomise as indicated in the section E of the fslvbm manual webpage and the Glm gui to create your statistical design. Cheers, Gwenaelle -------------------------------------------------------------------- Gwenaëlle Douaud, PhD FMRIB Centre, University of Oxford John Radcliffe Hospital, Headington OX3 9DU Oxford UK Tel: +44 (0) 1865 222 523 Fax: +44 (0) 1865 222 717 www.fmrib.ox.ac.uk/~douaud --------------------------------------------------------------------