Hi Josselin, If you have two groups (2 controls and 3 patients here) and are looking at the differences between the two with an additional covariate, what I mean by "model the mean" is something like: 1 0 -4 1 0 2 0 1 -2 0 1 0 0 1 4 (then there is no need of -D in randomise) instead of: 1.2 -4 1.2 2 -0.8 -2 -0.8 0 -0.8 4 (in which case you need -D in randomise) Cheers, Gwenaelle > De: Josselin Houenou <[log in to unmask]> > Objet: Re: [FSL] Re : [FSL] Covariables and demean > À: [log in to unmask] > Date: Samedi 12 mars 2011, 17h04 > Hi Gwenaelle, > > I have a quite trivial question about your answer. Let's > assume all the covariables have been demeaned. You say that > "run randomise with the -D option if you have not modelled > the mean for each group". What do you mean by "model the > mean for each group" ? > > Thanks, > Josselin -------------------------------------------------------------------- Gwenaëlle Douaud, PhD FMRIB Centre, University of Oxford John Radcliffe Hospital, Headington OX3 9DU Oxford UK Tel: +44 (0) 1865 222 523 Fax: +44 (0) 1865 222 717 www.fmrib.ox.ac.uk/~douaud --------------------------------------------------------------------