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Another problem with DTI studies is the lack of signal. Assume that one can reach isotropic resolution of 1.5mm by the means of segmented EPI sequence or insertable, head-only gradients. The SNR will be about 2.4 times smaller compared to the 2mm resolution by the virtue of smaller voxels. The SNR of the b=700 images on a 3T scanner is already pretty poor (~5-8). Further reduction in SNR will make the recostruction borderline unstable and you'll need to increase your imaging time by 4 times to combat this drop. peter -----Original Message----- From: FSL - FMRIB's Software Library [mailto:[log in to unmask]] On Behalf Of Matt Glasser Sent: Thursday, March 10, 2011 2:58 PM To: [log in to unmask] Subject: Re: [FSL] 2mm iso DTI @ 32dir Hi Jenifer, What are you trying to show with the diffusion data? 2mm isotropic is pretty standard (especially for a clinical population) though I would try to avoid anything worse than that at this point. If anything, you could improve things by acquiring more directions. It sounds like your reviewer might not be particularly familiar with the field as it stands... Peace, Matt. -----Original Message----- From: FSL - FMRIB's Software Library [mailto:[log in to unmask]] On Behalf Of Jenifer Juranek Sent: Thursday, March 10, 2011 2:29 PM To: [log in to unmask] Subject: [FSL] 2mm iso DTI @ 32dir Just curious if anyone has an idea about the following comment received from an anonymous reviewer: "Acquiring 32-direction DTI is positive but the 2mm isotropic resolution seems coarse for what is currently possible" Is there any recent development suggesting that 2mm isotropic dti is "coarse"? I'm not sure where this reviewer is coming from with this... Any ideas/suggestions for a response are greatly appreciated! Jenifer