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Did you repeat the low value (17 nmol/l) from
the Liaison on the Liaison?
Kent C.
Dooley PhD FCACB
Clinical Chemist
LifeLabs
3201 –
tel: 250 881-3100 ext.
2120
web: www.LifeLabs.com
From:
Clinical biochemistry discussion list [mailto:[log in to unmask]]
On Behalf Of Walsham Natalie
(LEWISHAM HEALTHCARE NHS TRUST)
Sent: Wednesday, March 09, 2011
8:07 AM
To:
[log in to unmask]
Subject: Abbott Vitamin D method
Dear all
I apologise for sending yet another
email about vitamin D methods but I am hoping to get feedback from anyone
evaluating or routinely using the new Abbott Architect 25-OH vitamin D assay.
We evaluated the Architect method
(twice) against the DiaSorin LIAISON 25-OH vitamin D assay and found
the Abbott results to have a positive bias with a y intercept of
14nmol/L even after major outliers were removed. Abbott claim that no
other user has seen this positive bias and that if there was significant 25-OH D2 in the samples then the
Architect should give lower results than the Liaison, and that other
precursors should not react in the Architect assay.
There was also a substantial difference between
methods for a couple of samples. One sample gave a result of 17 nmol/L on the
Liaison and 121 nmol/L on the Architect!!!
I would be grateful to hear from other Architect
users and their experience of the vitamin D method.
Many thanks
Regards
Natalie
Natalie Walsham DipRCPath
Lead Clinical Scientist
Tel: 020 3192 6980
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