Dear all
 
I apologise for sending yet another email about vitamin D methods but I am hoping to get feedback from anyone evaluating or routinely using the new Abbott Architect 25-OH vitamin D assay.
 
We evaluated the Architect method (twice) against the DiaSorin LIAISON 25-OH vitamin D assay and found the Abbott results to have a positive bias with a y intercept of 14nmol/L even after major outliers were removed. Abbott claim that no other user has seen this positive bias and that if there was significant 25-OH D2 in the samples then the Architect should give lower results than the Liaison, and that other precursors should not react in the Architect assay.

 

There was also a substantial difference between methods for a couple of samples. One sample gave a result of 17 nmol/L on the Liaison and 121 nmol/L on the Architect!!!

 

I would be grateful to hear from other Architect users and their experience of the vitamin D method.

 

Many thanks

 

Regards

Natalie


 
Natalie Walsham DipRCPath
Lead Clinical Scientist
University Hospital Lewisham
Tel: 020 3192 6980
 
 

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