"For those into trivia, Louis XII was particularly concerned with getting
out of this marriage so that he could marry the widowed Duchess of Brittany,
Anne; otherwise France would have lost the duchy. When Anne died without
producing a viable son and heir, Louis took Mary of York, who was less than
thrilled with the old king. When Louis died, and after the requisite period
of time to determine that Mary wasn't carrying a future king of France, Mary
was returned to the English court and her brother, Henry VIII. This opened
the way for Francis I."

 

For those heavily into trivia... Anne was the widow of Charles VIII of France. She was first married by proxy to Maximilian of Austria, and Charles was betrothed to his daughter, Marguerite. So Charles stole Max's bride and dumped his daughter. It is rumored that Anne wore a wedding dress supplied by Max. Louise of Savoy, mother of Francis I, spent much of her life fretting about Anne's pregnancies, of which there were many, and all of which ended in miscarriage, or death at birth or a very young age. The two women despised each other. Anne died at age 36 and would not have been pleased to see her daughter Claude married to Louise's son.