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A 3-year PhD studentship is available from October 2011 in the Biochemistry Department at the University of Leicester on "Structural and functional studies on mitotic NIMA-related kinases". The student will be based jointly in the laboratories of Richard Bayliss ([log in to unmask]) and Andrew Fry ([log in to unmask]), and informal enquiries can be sent to either supervisor. NIMA-related kinases are key regulators of mitosis, centrosomes and microtubules, and are a major focus of both laboratories. The Bayliss and Fry laboratories are housed within the flagship Henry Wellcome Building on the main University campus and are served by state-of-the-art facilities in structural biology and fluorescence microscopy. This project will provide the student with an excellent grounding in cutting-edge biochemical and molecular cell biology techniques. Hard-working, independent- minded and enthusiastic students who can work well in a team are encouraged to apply.

For examples of our recent work relevant to the project see:

1)     Richards MW, O’Regan L, Mas-Droux C, Blot JMY, Cheung J, Hoelder S, Fry AM, Bayliss R. (2009) An auto-inhibitory tyrosine motif in the cell cycle-regulated Nek7 kinase is released through binding of Nek9. Mol. Cell. 36(4):560-70. 

2) O'Regan L, Fry AM. (2009). The Nek6 and Nek7 protein kinases are required for robust mitotic spindle formation and cytokinesis. Mol Cell Biol. 29(14):3975-90.

Fry lab website: http://www2.le.ac.uk/departments/biochemistry/staff/fry

Eligibility: these awards are open to all applicants, but International  applicants (i.e. non UK/EU nationals/permanent residents) will be required to pay the difference between the International Registration fee (approx £9,500 p/a)