I sent this email again as I got no response. I would highly appreciate if any one could help me.

 
Dear FSL experts,

My question is about designing GLM for repeated measure ANOVA.

I have FA images from DTI scans for my subjcets. Each subject scanned in 5 different time points.

I want to design a GLM which shows areas with decreased FA between time point 1&2, 2&3, 3 &4 , 4&5 and also areas which shows linear decrease from time point 1 to time point 5.

I think for my first goal I should use ANOVA (1 factor-5 level), therefore for instance, for 2 subjects having scan in 5 time points, in order to show decrease FA between timepoint A&B, B&C, C&D and D&E, I should design:

Group               EV1     EV2       EV3           EV4          EV5      EV6        EV7
                     subj1  subj2    time1       time 2     time 3    time 4    time5
1                       1        0          1               0            0            0            0
1                       0       1           1              0            0            0            0
1                       1       0           0               1           0            0            0
1                       0        1          0               1           0             0           0
1                       1        0          0                0           1            0           0
1                       0        1           0               0           1            0           0
1                       1        0           0               0           0             1          0
1                       0         1          0               0            0            1          0
1                       1        0          0               0             0           0          1
1                       0        1          0               0             0           0           1

Contrasts        EV1      EV2     EV3           EV4         EV5       EV6        EV7
A-B                    0        0          1              -1             0             0          0      ( shows decrease FA between timepoint 1&2)
B-C                    0        0          0              1             -1            0          0
C-D                    0        0          0              0             1             -1          0
D-E                    0        0          0               0             0             1          -1

But I have no idea how I can show there is constant linear decrease from time point 1 to timepoint 5 ? I mean showing that FA1>FA2>FA3>FA4>FA5.

I would highly appreciate if any one could let me know if Iam correct for the first goal and how I can solve my second problem.

Best Regards,

Gelareh





--
Gelareh Ahmadi, MD
PhD Candidate
Neuroimaging Group
Howard Florey Institute
University of Melbourne
VIC, Australia, 3010

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