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I sent this email again as I got no response. I would highly appreciate if any one could help me. > Dear FSL experts, > > My question is about designing GLM for repeated measure ANOVA. > > I have FA images from DTI scans for my subjcets. Each subject scanned in 5 > different time points. > > I want to design a GLM which shows areas with decreased FA between time > point 1&2, 2&3, 3 &4 , 4&5 and also areas which shows linear decrease from > time point 1 to time point 5. > > I think for my first goal I should use ANOVA (1 factor-5 level), therefore > for instance, for 2 subjects having scan in 5 time points, in order to show > decrease FA between timepoint A&B, B&C, C&D and D&E, I should design: > > Group EV1 EV2 EV3 EV4 EV5 > EV6 EV7 > subj1 subj2 time1 time 2 time 3 time > 4 time5 > 1 1 0 1 0 0 > 0 0 > 1 0 1 1 0 0 > 0 0 > 1 1 0 0 1 0 > 0 0 > 1 0 1 0 1 0 > 0 0 > 1 1 0 0 0 1 > 0 0 > 1 0 1 0 0 1 > 0 0 > 1 1 0 0 0 0 > 1 0 > 1 0 1 0 0 0 > 1 0 > 1 1 0 0 0 0 > 0 1 > 1 0 1 0 0 0 > 0 1 > > Contrasts EV1 EV2 EV3 EV4 EV5 EV6 > EV7 > A-B 0 0 1 -1 0 > 0 0 ( shows decrease FA between timepoint 1&2) > B-C 0 0 0 1 -1 > 0 0 > C-D 0 0 0 0 1 > -1 0 > D-E 0 0 0 0 0 > 1 -1 > > But I have no idea how I can show there is constant linear decrease from > time point 1 to timepoint 5 ? I mean showing that FA1>FA2>FA3>FA4>FA5. > > I would highly appreciate if any one could let me know if Iam correct for > the first goal and how I can solve my second problem. > > Best Regards, > > Gelareh > > > -- Gelareh Ahmadi, MD PhD Candidate Neuroimaging Group Howard Florey Institute University of Melbourne VIC, Australia, 3010 ph +61 3 8344 1904 fax +61 3 9347 0446