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Table of contents
http://ebm.bmj.com/content/vol16/issue1/

Tuesday
1 February 2011

In this email

EBM Round-up

EBM round-up: February 2011

Richard Saitz

Electronic pages

Purpose and procedure

Editorials

Worldwide evidence-based medicine activities

Richard Saitz

Resource review

Resource review on: How to Read a Paper – the Basics of Evidence Based Medicine. Fourth edition. Oxford: Wiley-Blackwell 2010

Terrence Shaneyfelt

Therapeutics

Nateglinide does not reduce the incidence of diabetes or cardiovascular outcomes in people with impaired glucose tolerance and cardiovascular disease or risk factors

Giuseppe Derosa

Statins are not associated with a decrease in all cause mortality in a high-risk primary prevention setting

Bernhard M Kaess, Ramachandran S Vasan

Pregabalin is more effective than placebo for restless legs syndrome with mild adverse effects of daytime somnolence, headache and unsteadiness

Mark J Buchfuhrer

Low-dose rosiglitazone plus metformin reduces risk of incident type 2 diabetes compared with placebo in people with impaired glucose tolerance

Philip D Home

Large placebo-controlled RCT in myocardial infarction survivors finds that daily folic acid and vitamin B12 have no effect on risk of major vascular event

Alessandro Pezzini

Proton pump inhibitors given before endoscopy for upper gastrointestinal bleeding do not improve survival, rebleeding or need for surgery

Patrick Yachimski

In diabetic nephropathy, high doses of vitamin B decrease glomerular filtration rate and increase risk of the composite outcome of a vascular event or all-cause mortality compared with placebo

Vivek Bhalla

Allergen-specific immunotherapy improves asthma symptoms compared with placebo, but the possibility of adverse effects should be considered

Rabia Rashid, Anthony J Frew

In people with poorly controlled hypertension, self-management including telemonitoring is more effective than usual care for reducing systolic blood pressure at 6 and 12 months

Kenneth Earle

Diagnosis

An automated molecular test for Mycobacterium tuberculosis and resistance to rifampin (Xpert MTB/RIF) is sensitive and can be carried out in less than 2 h

Mark Melzer

Meta-analysis finds screening for prostate cancer with PSA does not reduce prostate cancer–related or all-cause mortality but results likely due to heterogeneity – the two highest quality studies identified do find prostate cancer–related mortality reductions

Monique J Roobol, Sigrid Carlsson, Jonas Hugosson

Prognosis

Odds of favourable 3-month outcome following ischaemic stroke are greatest when treatment with intravenous alteplase is initiated up to 90 min following event, with no benefit seen if alteplase is given after 270 min

Richard I Lindley

Prognostic value of CRP in stable coronary artery disease unclear due to a variety of biases in existing studies, therefore no clinical practice recommendations can be made

Vlado Perkovic, Rachel Huxley

Lowering systolic blood pressure below 130 mm Hg does not improve cardiovascular outcomes in hypertensive patients with diabetes and coronary artery disease

Michel Burnier, Grégoire Wuerzner

Aetiology

Increased consumption of green leafy vegetables, but not fruit, vegetables or fruit and vegetables combined, is associated with reduced incidence of type 2 diabetes

Katherine Esposito, Dario Giugliano

Long-term use of oral bisphosphonates increases the risk of oesophageal but not gastric or colorectal cancer

Mahyar Etminan

Does antiviral medication for treating herpes simplex during pregnancy increase the risk of birth defects in offspring?

De-Kun Li

In people with subclinical hypothyroidism, TSH level >10 mIU/l may predict increased risk of coronary heart disease and related mortality

Elizabeth N Pearce

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