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I'm trying to run a very large GLM with ~2000-4000 timepoints/voxel and ~220 regressors.  Currently, I'm doing this by feeding FSL individual slices - If I try to give FSL the entire 4D dataset it runs out of memory as you might expect.  However, for each slice, it still takes ~1 day to run.  Do anyone have suggestions for how to speed this up? 

Thanks,

Sam