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Deae SPMers,
 
I am going to use SPM for Cerebral Palsy Brain image analysis. Due to their abnormal or incomplete development of brain structures, I am wondering if SPM still work for such large brain deformation (for example, there is a large hole in some brian). Can SPM do registration and normalization among CP brains and health brains? If SPM does not work for this issue, could anyone recommend me a tool for it?
 
Any help will be highly appreciated. Thank you.
 
Chunxiao Zhou