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Dear Meikei, These are the internal globus pallidus [GPi] > during the ageing process they calcify, that would change FA and even reduce MR signal at EPI acquisitions (such as DTI) > it may explain why you get this 'artifact'. See you, edson Prof. Dr. Edson Amaro Jr Professor Associado - Dep Radiologia Faculdade de Medicina USP NIF Neuroimagem Funcional - LIM44 On Nov11, 2010, at 8:27 AM, meikei wrote: > Dear all, > > I got a DTI data which has two obvious dark holes at the middle point of the internal capsules, and there are hardly any tracts that can be visualized at that two black holes (see pictures, the two holes are highlighted by two green spheres). I wonder if it is a serious problem and what caused it, and if possible, how to avoid it? > > Thanks for your answer! > > Best wishes, > Meikei<Black holes.JPG>