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Dear Vladimir,

 　　Thanks for your transparent explanation, I understand it clearer. But I still have another question:  If we do souce recontrucion by using IMG method, I wonder if we extract several time series from a ROI and give them a average processing may be more accurate to summarize the activity in that area. As for this, could you give me some advice?

 　　I'm looking forward to your suggestion! Best wishes to you!