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Hi,

Am I correct, that you have a 2x2 design: 2 groups, 2 timepoints?
If that is the case you need a repeated-measure ANOVA:

http://mumford.bol.ucla.edu/setting_up_designs_2009.pdf (with courtesy to Jeanette Mumford)
78. slide

Bests,
Auer, Tibor M.D. Ph.D.
Biomedizinische NMR Forschungs GmbH
am Max-Planck Institut für Biophysikalische Chemie
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37077 Göttingen
Germany
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2010.11.22. 22:26 keltezéssel, Alan Francis írta:
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Hi FSL folks:
 
I am trying to look at differences between a group of 10 high risk converters (SZ) with an Age and Gender matched group of 10 high risk non converters at baseline and at follow-up. The matrix looks like this:
 
Subject Timepoint 1 Timepoint 2 T1-T2
High Risk Non Converters HR- T1 HR - T2 Change 1
High Risk Converters C - T1 C- T2 Change 2

Difference Difference








 
I have 4 sets of 10 brains each for the groups. I have run FSL-VBM at Timepoint 1 Diff, Timepoint 2 Diff, Change 1, and Change 2.
 
My question is : Does FSL allow one to run 4 groups to look at Change 1 - Change 2
 
When I go to the GLM set-up it allows one to only load 2 groups (paired or unpaired).
 
 Our goal is to examine which brain regions predict the onset of psychosis.
 
Any help is deeply appreciated
 
thank you,
 

 
Alan Francis
 
BIDMC/ Harvard