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Before we realised what was the cause of the problem we had checked the result, using both O'Leary and enzymatic assays. The problem isn't really analytical interference - the assay is simply measuring the increased creatinine which has just been administered to the patient intravenously along with the dexamethasone. Regards Denise ________________________________________ From: Indovina, Joe [OCDUS] [[log in to unmask]] Sent: 04 November 2010 20:51 To: Darby Denise (Christie Hospital NHS Foundation Trust); [log in to unmask] Subject: RE: Creatinine assay interference ? What type of creatinine assay is being used? -----Original Message----- From: Clinical biochemistry discussion list [mailto:[log in to unmask]] On Behalf Of Denise Darby Sent: Thursday, November 04, 2010 4:44 PM To: [log in to unmask] Subject: Re: Creatinine assay interference ? Dear All We have also recently just had a case of creatinine interference following IV dexamethasone despite not previously experiencing such problems. Discussion with pharmacy revealed that they have recently changed supplier to Hospira UK LTD which contains creatinine as an excipient unlike the previous brand we were using. Pharmacy suggested that there are problems nationwide with supply of the previous brand and most of the country is now using the Hospira brand. It might be worth checking with your pharmacy to see if they have also recently changed suppliers. Regards Denise Denise Darby Consultant Chemical Pathologist The Christie, Manchester ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk Green Laboratories Work http://www.laboratorymedicine.nhs.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/ ******************************************************************************************************************** This message may contain confidential information. If you are not the intended recipient please inform the sender that you have received the message in error before deleting it. Please do not disclose, copy or distribute information in this e-mail or take any action in reliance on its contents: to do so is strictly prohibited and may be unlawful. Thank you for your co-operation. NHSmail is the secure email and directory service available for all NHS staff in England and Scotland NHSmail is approved for exchanging patient data and other sensitive information with NHSmail and GSI recipients NHSmail provides an email address for your career in the NHS and can be accessed anywhere For more information and to find out how you can switch, visit www.connectingforhealth.nhs.uk/nhsmail ******************************************************************************************************************** ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk Green Laboratories Work http://www.laboratorymedicine.nhs.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/