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Hi all, I am trying to compare skeletonised data from two groups, but my control group is actually much larger than my experimental group (control n = 31, experimental n = 9). I know that the subtraction is corrected for multiple comparisons and is corrected for groups of different sizes, but I was wondering whether or not there is a limit to its ability to correct for groups of very different sizes. Is the fact that these two groups are so different size make a difference? Should I limit my control group size to something closer to the experimental group (assuming I randomly select for patients that are aged matched)? Thanks in advance. Mike DiSano